返回
當前專題

TP4030:Lieber-DeCarli標準型酒精液體模型飼料
Lieber-DeCarli Ethanol Liquid Diet(Regular type)

一、Lieber-DeCarli ethanol liquid diet(regular type)介紹


Lieber-DeCarli標準型(regular型)酒精液體模型飼料是一種高脂肪型酒精液體造模飼料,最初是為大鼠中研究酒精性脂肪肝(AFLD)而設計,后來已經廣泛應用于小鼠、兔、地鼠等動物各種酒精性疾病造模(見下文)。該模型飼料經過Lieber和DeCarli等研究者多次優化,形成了營養素較為合理的模型飼料。

Regular型Lieber-DeCarli酒精液體模型飼料
TP 4030A:酒精熱量36%(酒精含量:5%, wt/V,g/100毫升)

脂肪35%, 蛋白質18%, 碳水化合物11%, 酒精36%。點擊:展開↓

TP 4030B:酒精熱量28%(酒精含量:4%, wt/V,g/100毫升)

脂肪35%, 蛋白質18%, 碳水化合物19%, 酒精28%。點擊:展開↓

TP 4030D:酒精熱量28%(酒精含量:5%, V/V,毫升/100毫升)

脂肪35%, 蛋白質18%, 碳水化合物19%, 酒精28%。

用于小鼠酒精性脂肪肝造模的NIAAA法。點擊:展開↓

TP 4030C:以上模型飼料的酒精對照飼料

脂肪35%, 蛋白質18%, 碳水化合物47%。點擊:展開↓

基于
Regular型Lieber-DeCarli酒精液體模型飼料
修飾而成的模型飼料

Modified regular-type Lieber-DeCarli ethanol liquid diet

TP4030M1,以玉米油為主;TP4030M2,以魚油為主

酒精熱量36%(酒精含量:5%, wt/V,g/100毫升),脂肪35%, 蛋白質18%, 碳水化合物11%, 酒精36%。

點擊:展開↓

TP4030M3,以玉米油為主;TP4030M4,以魚油為主

酒精熱量28%(酒精含量:4%, wt/V,g/100毫升)
脂肪35%, 蛋白質18%, 碳水化合物19%, 酒精28%。點擊:展開↓


          推薦閱讀:酒精液體飼料常見疑問解答

二、TP4030標準型Lieber-DeCarli ethanol liquid diet的用途


(1)酒精性脂肪肝造模

Lieber-DeCarli標準型酒精液體模型飼料是一種高脂肪的酒精液體飼料,其中,脂肪熱量高達35%。研究已經表明,脂肪為35%是酒精性脂肪肝所必需達到的水平。

(2)依賴于高脂的酒精性器官損傷的作用及其機理研究。例如,對胰腺功能的研究。

(3)用于不同脂肪情況下酒精效應的比較研究。

Lieber-DeCarli酒精液體Regular型飼料的用途
廣泛應用于大鼠、小鼠、兔、地鼠等動物:

(1)酒精性脂肪肝(AFLD)模型,酒精性心肌病(ACM)的復制;

(2)酒精性肝損傷模型的復制;

(3)酒精性胰腺炎模型的復制

(4)藥物、食品功能因子、保健食品對酒精性脂肪肝的對抗作用;

(5)藥物、食品功能因子、保健食品對酒精的解毒作用;

(6)酒精成癮的機制;

(7)酒精所致生理機能的改變及其機制。

(8)酒精與毒素(環境、食物、微生物的毒素)對機體的相互作用。

請注意動物不同種系、品系、年齡、性別的差異。

三、Lieber-DeCarli ethanol liquid Diet應用的注意點


關于Lieber-DeCarli酒精液體模型飼料的詳細介紹,請點擊“Lieber-DeCarli酒精液體飼料和注意事項”。

1.購買飼料前:

(1)如果選擇飼料代碼為TP4030M1,請注意與另一個模型飼料代碼TP4231的酒精液體飼料進行對比后根據動物情況和對脂肪的要求綜合確定。

(2)應當做好動物的準備,注意動物的品種、品系、年齡、性別的選擇。

(3)準備好喂養流程的準備。

2. 購買后應當及時向公司索取以下資料:

《酒精液體飼料配制方法》

《酒精液體飼料喂養方法》

 

References:

Nan YM, Kong LB, Ren WG, Wang RQ, Du JH, Li WC, Zhao SX, Zhang YG, Wu WJ, Di HL, Li Y, Yu J. Activation of peroxisome proliferator activated receptor alpha ameliorates ethanol mediated liver fibrosis in mice. Lipids Health Dis. 2013 Feb 6;12:11.

Yin H, Hu M, Zhang R, Shen Z, Flatow L, You M. MicroRNA-217 promotes ethanol-induced fat accumulation in hepatocytes by down-regulating SIRT1. J Biol Chem. 2012 Mar 23;287(13):9817-26.

Zhao P, Slattery JT. Effects of ethanol dose and ethanol withdrawal on rat liver mitochondrial glutathione: implication of potentiated acetaminophen toxicity in alcoholics. Drug Metab Dispos. 2002 Dec;30(12):1413-7.

Hamilton SR, Sohn OS, Fiala ES. Effects of timing and quantity of chronic dietary ethanol consumption on azoxymethane-induced colonic carcinogenesis and azoxymethane metabolism in Fischer 344 rats. Cancer Res. 1987 Aug 15;47(16):4305-11.

Madesh M, Zong WX, Hawkins BJ, Ramasamy S, Venkatachalam T, Mukhopadhyay P, Doonan PJ, Irrinki KM, Rajesh M, Pacher P, Thompson CB.Execution of superoxide-induced cell death by the proapoptotic Bcl-2-related proteins Bid and Bak. Mol Cell Biol. 2009 Jun;29(11):3099-112.

Lindi C, Montorfano G, Marciani P. Rat erythrocyte susceptibility to lipid peroxidation after chronic ethanol intake. Alcohol. 1998 Nov;16(4):311-6.

Chen LH, Xi S, Cohen DA. Liver antioxidant defenses in mice fed ethanol and the AIN-76A diet. Alcohol. 1995 Sep-Oct;12(5):453-7.

Dobrzyńska I. Szachowicz-Petelska B, Skrzydlewska E. Figaszewski Z. Effects of green tea on physico-chemical properties of liver cell membranes of rats intoxicated with ethanol. Polish J. of Environ. Stud. Vol. 17, No. 3 (2008),327-333.

Yin HQ, Kim YC, Chung YS, Kim YC, Shin YK, Lee BH. Honokiol reverses alcoholic fatty liver by inhibiting the maturation of sterol regulatory element binding protein-1c and the expression of its downstream lipogenesis genes. Toxicol Appl Pharmacol. 2009 Apr 1;236(1):124-30.

García-Ruiz C, Morales A, Ballesta A, Rodés J, Kaplowitz N, Fernández-Checa JC. Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes. J Clin Invest. 1994 Jul;94(1):193-201.

Li HH, Doiron K, Patterson AD, Gonzalez FJ, Fornace Jr AJ. Identification of serum insulin-like growth factor binding protein 1 as diagnostic biomarker for early-stage alcohol-induced liver disease. J Transl Med. 2013 Oct 23;11(1):266.

Pandey SC, Ugale R, Zhang H, Tang L, Prakash A. Brain chromatin remodeling: a novel mechanism of alcoholism. J Neurosci. 2008 Apr 2;28(14):3729-37.

Aroor AR, Roy LJ, Restrepo RJ, Mooney BP, Shukla SD. A proteomic analysis of liver after ethanol binge in chronically ethanol treated rats.Proteome Sci. 2012 Apr 30;10(1):29.

Wang TT, Pak YK, Weiner H. Effects of alcohol on the import of aldehyde dehydrogenase precursor into rat liver mitochondria. Alcohol Clin Exp Res. 1990 Aug;14(4):600-4.

Izabela Dobrzyńska, Barbara Szachowicz-Petelska,El?bieta Skrzydlewska and Zbigniew A. FigaszewskiProtective effect of green tea on electric properties of rat erythrocyte membrane during ethanol intoxication. Journal of Environmental Biology. April 2006,27(2) 161-166 (2006)

Ting-A-Kee R, Vargas-Perez H, Bufalino MR, Bahi A, Dreyer JL, Tyndale RF, van der Kooy D. Infusion of brain-derived neurotrophic factor into the ventral tegmental area switches the substrates mediating ethanol motivation. Eur J Neurosci. 2013 Mar;37(6):996-1003.

Fisher H, Halladay A, Ramasubramaniam N, Petrucci JC, Dagounis D, Sekowski A, Martin JV, Wagner GC. Liver fat and plasma ethanol are sharply lower in rats fed ethanol in conjunction with high carbohydrate compared with high fat diets. J Nutr. 2002 Sep;132(9):2732-6.

Mirovsky, Y., Wagner, G. C., Sekowski, A., Goldberg, M. & Fisher, H. (1995) Simultaneous changes in striatal dopamine, serotonin, and metabolites after withdrawal seizures in rats from dependence on alcohol. Alcohol 12:251-256.

Piano MR, Artwohl J, Kim SD, Gass G. The effects of a liquid ethanol diet on nutritional status and fluid balance in the rat. Alcohol Alcohol. 2001 Jul-Aug;36(4):298-303.

Cornier MA, Gayles EC, Bessesen DH. The effects of chronic ethanol consumption on energy balance in rats. Metabolism. 2002 Jun;51(6):787-91.

Cooling J, Blundell J. Differences in energy expenditure and substrate oxidation between habitual high fat and low fat consumers (phenotypes). Int J Obes Relat Metab Disord. 1998 Jul;22(7):612-8.

de Fiebre NC, de Fiebre CM. Freely accessible water does not decrease consumption of ethanol liquid diets.Alcohol. 2003 Feb;29(2):61-8.

Anji A, Kumari M. Supplementing the liquid alcohol diet with chow enhances alcohol intake in C57 BL/6 mice.Drug Alcohol Depend. 2008 Sep 1;97(1-2):86-93.

Piano MR, Carrigan TM, Schwertz DW. Sex differences in ethanol liquid diet consumption in Sprague-Dawley rats. Alcohol. 2005 Feb;35(2):113-8

D'Souza El-Guindy NB, Kovacs EJ, De Witte P, Spies C, Littleton JM, de Villiers WJ, Lott AJ, Plackett TP, Lanzke N, Meadows GG. Laboratory models available to study alcohol-induced organ damage and immune variations: choosing the appropriate model.Alcohol Clin Exp Res. 2010 Sep 1;34(9):1489-511.

Clugston RD, Jiang H, Lee MX, Piantedosi R, Yuen JJ, Ramakrishnan R, Lewis MJ, Gottesman ME, Huang LS, Goldberg IJ, Berk PD, Blaner WS. Altered hepatic lipid metabolism in C57BL/6 mice fed alcohol: a targeted lipidomic and gene expression study. J Lipid Res. 2011 Nov;52(11):2021-31.

Bertola A, Mathews S, Ki SH, Wang H, Gao B. Mouse model of chronic and binge ethanol feeding (the NIAAA model). Nat Protoc. 2013 Mar;8(3):627-37.

Ki SH, Park O, Zheng M, Morales-Ibanez O, Kolls JK, Bataller R, Gao B. Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: role of signal transducer and activator of transcription 3. Hepatology. 2010 Oct;52(4):1291-300.

Sharda DR, Miller-Lee JL, Kanski GM, Hunter JC, Lang CH, Kennett MJ, Korzick DH. Comparison of the agar block and Lieber-DeCarli diets to study chronic alcohol consumption in an aging model of Fischer 344 female rats. J Pharmacol Toxicol Methods. 2012 Nov-Dec;66(3):257-63.

Dolganiuc A, Petrasek J, Kodys K, Catalano D, Mandrekar P, Velayudham A, Szabo G. MicroRNA expression profile in Lieber-DeCarli diet-induced alcoholic and methionine choline deficient diet-induced nonalcoholic steatohepatitis models in mice. Alcohol Clin Exp Res. 2009 Oct;33(10):1704-10.

Gyamfi MA, Damjanov I, French S, Wan YJ. The pathogenesis of ethanol versus methionine and choline deficient diet-induced liver injury. Biochem Pharmacol. 2008 Feb 15;75(4):981-95.

Augustyniak A, Waszkiewicz E, Skrzydlewska E. Preventive action of green tea from changes in the liver antioxidant abilities of different aged rats intoxicated with ethanol. Nutrition. 2005;21:925–932.

Rajasingh J, Bord E, Qin G, Ii M, Silver M, Hamada H, Ahluwalia D, Goukassian D, Zhu Y, Losordo DW, Kishore R. Enhanced voluntary alcohol consumption after estrogen supplementation negates estrogen-mediated vascular repair in ovariectomized mice. Endocrinology. 2007;148:3618–3624.

Gavaler JS, Smith WI, Jr., Van Thiel DH, Rosenblum ER, Deal SR, Allan MJ. “Binge” versus steady drinking: effects on the liver in the ovariectomized rat. Alcohol Clin Exp Res. 1993;17:355–358.

Jung KI, Ju A, Lee HM, Lee SS, Song CH, Won WY, Jeong JS, Hong OK, Kim JH, Kim DJ. Chronic ethanol ingestion, type 2 diabetes mellitus, and brain-derived neurotrophic factor (BDNF) in rats. Neurosci Lett. 2010;487:149–152.

Roberts BJ, Shoaf SE, Song BJ. Rapid changes in cytochrome P4502E1 (CYP2E1) activity and other P450 isozymes following ethanol withdrawal in rats. Biochem Pharmacol. 1995 May 26;49(11):1665-73.

Eid N, Ito Y, Otsuki Y. Anti-Apoptotic Mechanisms of Sertoli Cells against Ethanol Toxicity. J Alcoholism Drug Depend. January 28, 2013.

Kong L, Ren W, Li W, Zhao S, Mi H, Wang R, Zhang Y, Wu W, Nan Y, Yu J. Activation of peroxisome proliferator activated receptor alpha ameliorates ethanol induced steatohepatitis in mice. Lipids Health Dis. 2011 Dec 30;10:246.

Shen Z, Liang X, Rogers CQ, Rideout D, You M. Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice. Am J Physiol Gastrointest Liver Physiol. 2010 Mar;298(3):G364-74.

Ajmo JM, Liang X, Rogers CQ, Pennock B, You M. Resveratrol alleviates alcoholic fatty liver in mice. Am J Physiol Gastrointest Liver Physiol. 2008 Oct;295(4):G833-42.

Denucci SM, Tong M, Longato L, Lawton M, Setshedi M, Carlson RI, Wands JR, de la Monte SM. Rat strain differences in susceptibility to alcohol-induced chronic liver injury and hepatic insulin resistance. Gastroenterol Res Pract. 2010

Dlugos CA. Smooth endoplasmic reticulum dilation and degeneration in Purkinje neuron dendrites of aging ethanol-fed female rats. Cerebellum. 2006;5:155–162.

Dlugos CA, Pentney RJ. Morphometric evidence that the total number of synapses on Purkinje neurons of old F344 rats is reduced after long-term ethanol treatment and restored to control levels after recovery. Alcohol Alcohol. 1997;32:161–172.

Eagon PK. Alcoholic liver injury: influence of gender and hormones. World J Gastroenterol. 2010;16:1377–1384.

Eagon PK, Elm MS, Tadic SD, Nanji AA. Downregulation of nuclear sex steroid receptor activity correlates with severity of alcoholic liver injury. Am J Physiol Gastrointest Liver Physiol. 2001;281:G342–349.

Erickson CK. Ethanol clearance in nine inbred rat strains. Alcohol Clin Exp Res. 1984;8:491–494.

Fauchier L, Babuty D, Poret P, Casset-Senon D, Autret ML, Cosnay P, Fauchier JP. Comparison of long-term outcome of alcoholic and idiopathic dilated cardiomyopathy. Eur Heart J. 2000;21:306–314.

Fernandez-Sola J, Estruch R, Nicolas JM, Pare JC, Sacanella E, Antunez E, Urbano-Marquez A. Comparison of alcoholic cardiomyopathy in women versus men. Am J Cardiol. 1997;80:481–485.

Fogle RL, Hollenbeak CS, Stanley BA, Vary TC, Kimball SR, Lynch CJ. Functional proteomic analysis reveals sex-dependent differences in structural and energy-producing myocardial proteins in rat model of alcoholic cardiomyopathy. Physiol Genomics. 2011;43:346–356.

Fogle RL, Lynch CJ, Palopoli M, Deiter G, Stanley BA, Vary TC. Impact of Chronic Alcohol Ingestion on Cardiac Muscle Protein Expression. Alcohol Clin Exp Res. 2010;34:1226–1234.

Gutierrez-Grobe Y, Ponciano-Rodriguez G, Ramos MH, Uribe M, Mendez-Sanchez N. Prevalence of non alcoholic fatty liver disease in premenopausal, posmenopausal and polycystic ovary syndrome women. The role of estrogens. Ann Hepatol. 2010;9:402–409.

Hunter JC, Korzick DH. Age- and sex-dependent alterations in protein kinase C (PKC) and extracellular regulated kinase 1/2 (ERK1/2) in rat myocardium. Mech Ageing Dev. 2005;126:535–550.

J?rvel?inen HA, J?rvel?Lukkari TA, Heinaro S, Sippel H, Lindros KO. The antiestrogen toremifene protects against alcoholic liver injury in female rats. Journal of Hepatology. 2001;35:46–52.

Kano M, Ishikawa F, Matsubara S, Kikuchi-Hayakawa H, Shimakawa Y. Soymilk products affect ethanol absorption and metabolism in rats during acute and chronic ethanol intake. J Nutr. 2002;132:238–244.

Khanna JM, Kalant H, Shah G, Sharma H. Comparison of sensitivity and alcohol consumption in four outbred strains of rats. Alcohol. 1990;7:429–434.

Lang CH, Fan J, Lipton BP, Potter BJ, McDonough KH. Modulation of the insulin-like growth factor system by chronic alcohol feeding. Alcohol Clin Exp Res. 1998;22:823–829.

Laonigro I, Correale M, Di Biase M, Altomare E. Alcohol abuse and heart failure. Eur J Heart Fail. 2009;11:453–462.

Li T, Lumeng L. Alcohol preference and voluntary alcohol intakes of inbred rat strains and the national institutes of health heterogeneous stock of rats. Alcohol Clin Exp Res. 1984;8:485–486.

Lieber CS, DeCarli LM. Liquid diet technique of ethanol administration: 1989 update. Alcohol Alcohol. 1989;24:197–211.

Lieber CS, Jones DP, Decarli LM. Effects of prolonged ethanol intake: production of fatty liver despite adequate diets. J Clin Invest. 1965;44:1009–1021.

Lin RC, Li TK. Effects of isoflavones on alcohol pharmacokinetics and alcohol-drinking behavior in rats. Am J Clin Nutr. 1998;68:1512S–1515S.

Lindros KO, Stowell L, V??n?nen H, Sipponen P, Lamminsivu U, Pikkarainen P, Salaspuro M. Uninterrupted prolonged ethanol oxidation as a main pathogenetic factor of alcoholic liver damage: evidence from a new liquid diet animal model. Liver. 1983;3:79–91.

Maddrey WC. Alcohol-induced liver disease. Clin Liver Dis. 2000;4:115–131.

McKenna CJ, Codd MB, McCann HA, Sugrue DD. Alcohol consumption and idiopathic dilated cardiomyopathy: a case control study. Am Heart J. 1998;135:833–837.

Novotny JL, Simpson AM, Tomicek NJ, Lancaster TS, Korzick DH. Rapid estrogen receptor-alpha activation improves ischemic tolerance in aged female rats through a novel protein kinase C epsilon-dependent mechanism. Endocrinology. 2009;150:889–896.

Ott JF, Hunter BE, Walker DW. The effect of age on ethanol metabolism and on the hypothermic and hypnotic responses to ethanol in the Fischer 344 rat. Alcohol Clin Exp Res. 1985;9:59–65.

Paquette A, Shinoda M, Lhoret RR, Prud’homme D, Lavoie J-M. Time course of liver lipid infiltration in ovariectomized rats: Impact of a high-fat diet. Maturitas. 2007;58:182–190.

Pentney RJ, Mullan BA, Felong AM, Dlugos CA. The total numbers of cerebellar granule neurons in young and aged Fischer 344 and Wistar-Kyoto rats do not change as a result of lengthy ethanol treatment. Cerebellum. 2002;1:79–89.

Pentney RJ, Quackenbush LJ. Dendritic hypertrophy in Purkinje neurons of old Fischer 344 rats after long-term ethanol treatment. Alcohol Clin Exp Res. 1990;14:878–886.

Rachamin G, MacDonald JA, Wahid S, Clapp JJ, Khanna JM, Israel Y. Modulation of alcohol dehydrogenase and ethanol metabolism by sex hormones in the spontaneously hypertensive rat. Effect of chronic ethanol administration. Biochem J. 1980;186:483–490.

Rikans LE, Kling OR. Effects of aging and testosterone administration on liver alcohol dehydrogenase activity in male Fischer 344 rats. Alcohol Clin Exp Res. 1987;11:562–566.

Savonenko AV, Markowska AL. The cognitive effects of ovariectomy and estrogen replacement are modulated by aging. Neuroscience. 2003;119:821–830.

Sone K, Yamamoto-Sawamura T, Kuwahara S, Nishijima K, Ohno T, Aoyama H, Tanaka S. Changes of estrous cycles with aging in female F344/n rats. Exp Anim. 2007;56:139–148.

Tadic SD, Elm MS, Li H-S, Van Londen GJ, Subbotin VM, Whitcomb DC, Eagon PK. Sex differences in hepatic gene expression in a rat model of ethanol-induced liver injury. Journal of Applied Physiology. 2002;93:1057–1068.

Tajuddin NF, Druse MJ. Effects of chronic alcohol consumption and aging on dopamine D2 receptors in Fischer 344 rats. Alcohol Clin Exp Res. 1996;20:144–151.

Urbano-Marquez A, Estruch R, Fernandez-Sola J, Nicolas JM, Pare JC, Rubin E. The greater risk of alcoholic cardiomyopathy and myopathy in women compared with men. JAMA. 1995;274:149–154.

Vary TC, Kimball SR, Sumner A. Sex-dependent differences in the regulation of myocardial protein synthesis following long-term ethanol consumption. Am J Physiol Regul Integr Comp Physiol. 2007;292:R778–R787.

Vary TC, Lynch CJ, Lang CH. Effects of chronic alcohol consumption on regulation of myocardial protein synthesis. Am J Physiol Heart Circ Physiol. 2001;281:H1242–1251.

Yin M, Ikejima K, Wheeler MD, Bradford BU, Seabra V, Forman DT, Sato N, Thurman RG. Estrogen is involved in early alcohol-induced liver injury in a rat enteral feeding model. Hepatology. 2000;31:117–123.

Zhu P, Zhou HZ, Gray MO. Chronic ethanol-induced myocardial protection requires activation of mitochondrial K(ATP) channels. J Mol Cell Cardiol. 2000;32:2091–2095.

Singh M. Effect of chronic ethanol feeding on factors leading to inappropriate intrapancreatic activation of zymogens in the rat pancreas. Digestion. 1992;53(1-2):114-20.

Purohit V, Rapaka R, Shurtleff D. Role of cannabinoids in the development of fatty liver (steatosis). AAPS J. 2010 Jun;12(2):233-7.

Zhong Z, Connor HD, Mason RP, Lemasters JJ, Thurman RG. Ethanol, not fat accumulation per se, increases free radical production in a low-flow, reflow liver perfusion model. Transplantation. 1998 Dec 15;66(11):1431-8.

Lieber CS, Jones DP, Mendelson J, DeCarli LM: Fatty liver, hyperlipemia and hyperuricemia produced by prolonged alcohol consumption despite adequate dietary intake. Trans Ass Amer Physicians 76:289-300, 1963.

Best CH, Hartroft WS, Lucas CC, Ridout JH: Liver damage produced by feeding alcohol or sugar and its prevention by choline. Brit Med J lI:1001-1006, 1949.

Lieber CS: Medical Disorders of Alcoholism: Pathogenesis and Treatment. W. B. Saunders Company, Philadelphia, 1982.

Saville PD, Lieber CS: Increases in skeletal calcium and femur cortex thickness produced by undemutrition. J Nutr 99:141-144, 1969.

Lieber CS, Jones DP, DeCarli LM: Effects of prolonged ethanol intake: Production of fatty liver despite adequate diets. J Clin Invest 44:1009-1021, 1965.

Saville PD, Lieber CS: Effect of alcohol on growth, bone density and muscle magnesium in the rat. J Nutr 87:477-484, 1965

Pirola RC, Lieber CS: Energy wastage in rats given drugs that induce microsomal enzyme. J Nutr 105:1544-1548, 1975.

Pirola RC, Lieber CS: Energy wastage in alcoholism and drug abuse: Possible role of hepatic microsomal enzymes. Amer J Clin Nutr 29:90-93, 1976.

Pirola RC, Lieber CS: The energy cost of the metabolism of drugs, including ethanol. Pharmacology 7: 185-196, 1972.

Lieber CS: Chronic alcoholic hepatic injury in experimental animals and man: Biochemical pathways and nutritional factors. Fed Proc 26:1443-1448, 1967.

Lieber CS, Spritz N, DeCarli LM: Role of dietary, adipose and endogenously synthesized fatty acids in the pathogenesis of the alcoholic fatty liver. J Clin Invest 455, 1- 62. 1966.

Lieber CS, Lcfevre A, Spritz N, Feinman L, DeCarli LM: Difference in hepatic metabolism of long and mediumchain fatty acids The role of fatty acid chain length in the production of the alcoholic fatty liver. J Clin Invest 46: 1451-1460, 1967.

Lieber CS, DeCarli LM: Study of agents for the prevention of the fatty liver produced by prolonged alcohol intake. Gastroenterology 503, 16-322, 1966.

Iseri OA, Lieber CS, Gottlieb LS: The ultrastructure of fatty liver induced by prolonged ethanol ingestion. Am J Pathol 48:535-555, 1966.

DeCarli LM, Lieber CS: Fatty liver in the rat after prolonged intake of ethanol with a nutritionally adequate new liquid diet. J Nutr 91:331-336, 1967.

Lieber CS, DeCarli LM: Quantitative relationshp between the amount of dietary fat and the severity of the alcoholic fatty liver. Am J Clin Nutr 23:474-478, 1970.

Wiener SG, Shoemaker WJ, Koda LY, Bloom FE: Interaction of ethanol and nutrition during gestation: Influence on maternal and offspring development in the rat. J Pharmacol Exper Ther 216,572-579, 1981.

Lieber CS: Alcohol, protein metabolism and liver injury. Gastroenterology 79:373-390, 1980.

Lieber CS: Effects of ethanol upon lipid metabolism. Lipids 9: 103- 116, 1974.

Lieber CS, DeCarli LM: Ethanol dependence and tolerance: A nutritionally controlled experimental model in the rat. Res Commun Chem Path Pharmacol 6:983-991, I973.

Lieber CS, DeCarli LM: Hepatic microsomal ethanol oxidizing system: In vitro characteristics and adaptive prop erties in vivo. J Biol Chem 245:2505-2512, 1970.

Ohnishi K, Lieber CS: Reconstitution of the microsoma1 ethanol oxidizing system (MEOS): Qualitative and quantitative changes of cytochrome P-450 after chronic ethanol consumption. J Biol Chem 252:7124-7131, 1977.

Lieber CS, DeCarli LM: The role of the hepatic microsomal ethanol oxidizing system (MEOS) for ethanol metabolism in vivo. J Pharmacol Exp Ther 181:279-287, 1972.

Lieber CS. Seitz HK, Garro AJ, Worner TM: Alcohol related diseases and carcinogenesis. Cancer Res 39:2863- 2886, 1979.

Lieber CS: Interaction of ethanol with drug toxicity. Am J Gastroenterol 74:313-320, 1980.

National Research Council, Committee on Animal Nutrition. Nutrient requirements of laboratory animals, publ. 990. National Academy of Sciences-National Research Council, Washington, DC, 1962.

Lieber CS, DeCarli LM: Alcoholic fatty liver. Model No. 30, Supplemental Update, 1980, in Capen CC, Hackel DB, Jones JC, Migaki G, (eds): Handbook: Animal Models of Human Disease, Fasc 2. Registry of Comparative Pathology, Armed Forces Institute of Pathology, Washington, DC, 1980 .

Miller SS, Goldman ME, Erickson CK, Shorey RL: Induction of physical dependence on and tolerancc to ethanol in rats fed a new nutritionally complete and balanced liquid diet. Psychopharmacology 683-59, 1980.

Freund G: Alcohol consumption and its circadian distribution in mice. J Nutr 100:30-36, 1970.

Lieber CS, DeCarli LM: An experimental model of alcohol feeding and liver injury in the baboon. J Med Primatol, 3:153-163, 1974.

Lieber CS, DeCarlj LM, Rubin E: Sequential production of fatty liver, hepatitis and cirrhosis in sub-human primates fed ethanol with adequate diets. Proc Natl Acad Sci USA 72:437-441, 1975.

Popper H, Lieber CS: Histogenesis of alcoholic fibrosis and cirrhosis in the baboon. Am J Pathol 98:695-716, 1980.

Peterson DR, Atkinson N: Evidence for a genetic basis of microsomal ethanol oxidation (MEOS) induction in mice, in Erikson K, Sinclair JD, Kiianmaa K (eds): Animal Models in Research. New York, Academic Press, 1980, pp 71-79.

Shaw S, Gorkin BD, Lieber CS: Effects of chronic alcohol feeding on thiamine status: biochemical and neurological correlates. Am J Clin Nutr 34:856-860, 1981.

Sato M, Lieber CS Hepatic vitamin A depletion after chronic ethanol consumption in baboons and rats. J Nutr. 111:2015-2023, 1981.

Leo MA, Arai M, Sato M, Lieber CS: Hepatotoxicity of moderate vitamin A supplementation in the rat. Gastroenterology 82: 194-205, 1982.

Handbook of Clinical Dietetics, American Dietetic Association, New Haven, Yale University Press, 1981.

Filiano AN, Millender-Swain T, Johnson R Jr, Young ME, Gamble KL, Bailey SM. Chronic ethanol consumption disrupts the core molecular clock and diurnal rhythms of metabolic genes in the liver without affecting the suprachiasmatic nucleus. PLoS One. 2013 Aug 12;8(8):e71684.



有困惑?那就商量唄!

液體飼料的優點,你可以充分運用!

---------《》-------

marker可以任意缺乏或過載某營養素

marker可以任意添加藥物或測試成分

marker可以精確定量飼料攝入量

marker可以任意定制飼料


使用南通特洛菲飼料科技有限公司生產的大鼠、小鼠酒精液體模型飼料發表的論文選登

Guo JM, Liu AJ, Zang P, Dong WZ, Ying L, Wang W, Xu P, Song XR, Cai J, Zhang SQ, Duan JL, Mehta JL, Su DF. ALDH2 protects against stroke by clearing 4-HNE.

Cell Res.2013,23(7):915-930.

Pubmed】【全文】【新聞

注:Cell Reseach,縮寫Cell Res.為Nature的子刊,影響因子10.526. 以上論文是由第二軍醫大學領銜的國內外7個研究機構聯合開展研究的論文。

Nan YM, Kong LB, Ren WG, Wang RQ, Du JH, Li WC, Zhao SX, Zhang YG, Wu WJ, Di HL, Li Y,Yu J. Activation of peroxisome proliferator activated receptor alpha ameliorates ethanol mediated liver fibrosis in mice.

Lipids Health Dis.2013,12:11.

Pubmed】【全文

Cao YW, Jiang Y, Zhang DY, Wang M, Chen WS, Su H, Wang YT, Wan JB. Protective effects of Penthorum chinense Pursh against chronic ethanol-induced liver injury in mice.

Journal of Ethnopharmacology, 2015, 161:92–98.

Pubmed】【全文

注:澳門大學和第二軍醫大學等三個單位聯合開展研究的論文。

Wu XQ, Yang Y, Li WX Cheng YH, Li XF, Huang C, Meng XM, Wu BM, Liu XH, Zhang L, Lv XW, Li J. Telomerase reverse transcriptase acts in a feedback loop with NF-κB pathway to regulate macrophage polarization in alcoholic liver disease.

Sci Rep. 2016 Jan 4;6:18685.

Pubmed】【全文

注:Scientific Reports,縮寫Sci Rep.是Nature新誕生的子刊,影響因子5.578,以強勁勢頭攀升。

Wang M, Zhang XJ, Feng K, He C, Li P, Hu YJ, Su H, Wan JB. Dietary α-linolenic acid-rich flaxseed oil prevents against alcoholic hepatic steatosis via ameliorating lipid homeostasis at adipose tissue-liver axis in mice.

Sci Rep. 2016 May 25;6:26826.

Pubmed】【全文

Liu F, Bai X, Ding RB, Hu YJ, Su H, Wan JB. UPLC/Q-TOFMS-Based Metabolomics Studies on the Protective Effect of Panax notoginseng Saponins on Alcoholic Liver Injury.

Am J Chin Med. 2015;43(4):695-714.

Pubmed】【全文

Song X, Yin S, Huo Y, Liang M, Fan L, Ye M, Hu H. Glycycoumarin ameliorates alcohol-induced hepatotoxicity via activation of Nrf2 and autophagy

Free Radic Biol Med. 2015 Dec;89:135-46.

Pubmed】【全文


小幫手
關閉
收藏本網站
丝瓜苹果下载ios二维码_丝瓜app官网版ios下载_丝瓜app向日葵app幸福宝