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動脈粥樣硬化模型


Quail(鵪鶉)

鵪鶉動脈粥樣硬化模型飼料
和造模注意事項
Model Diet of Atherosclerosis in Quails

大量研究采用鵪鶉(quail)研究動脈粥樣硬化和用于動脈粥樣硬化模型復制。研究中多采用日本鵪鶉。

一、鵪鶉動脈粥樣硬化模型造模的特點


鵪鶉作為人類動脈粥樣硬化模型動物,具有以下方面的表現:

(1)鵪鶉的血漿膽固醇濃度對飼料中膽固醇很敏感;

(2)模型飼料引起的血漿膽固醇升高,主要是在LDL和VLDL;

(3)血漿膽固醇濃度升高與動脈粥樣硬化的嚴重程度關聯。

(4)動脈粥樣硬化斑塊形成類似人類動脈粥樣硬化的高級階段,包括內膜增厚、水腫、壞死、肥厚,動脈狹窄,梗死。

(5)動脈粥樣硬化模型的重復性好。

Quail atherosclerosis鵪鶉動脈粥樣硬化與血漿膽固醇的關系

二、鵪鶉動脈粥樣硬化模型造模方法和模型飼料


鵪鶉動脈粥樣硬化模型飼料包括:高脂高膽固醇模型飼料,高膽固醇模型飼料。右圖是鵪鶉動脈粥樣硬化模型發展程度與血漿膽固醇的關系。因此,鵪鶉的動脈粥樣硬化最為關鍵的是血漿膽固醇濃度,只要升高血漿膽固醇,動脈粥樣硬化發展只是遲早的事。

1.鵪鶉動脈粥樣硬化用高膽固醇模型飼料

從圖中可以看到,鵪鶉的動脈粥樣硬化發展程度與血漿膽固醇濃度成正比。因此,選用高膽固醇模型飼料時,如果希望成模更快,應當選擇膽固醇含量較高的模型飼料。

但是,模型飼料中膽固醇含量較高時,血漿膽固醇濃度過高,可能引起動物攝食量降低。

下面是南通特洛菲飼料科技有限公司生產的適用于鵪鶉動脈粥樣硬化的高膽固醇模型飼料。

特洛菲飼料科技有限公司
鵪鶉高膽固醇模型飼料

日糧型

以下模型飼料是在本公司鵪鶉標準飼料(低脂)生產過程中添加膽固醇,其正常對照飼料應當選用相應的低脂型鵪鶉標準飼料

產品代碼     模型飼料名稱             說明

TP 3Q002:鵪鶉高膽固醇模型飼料,0.5%膽固醇

TP 3Q004:鵪鶉高膽固醇模型飼料,1%膽固醇

TP 3Q006:鵪鶉高膽固醇模型飼料,2%膽固醇

TP 3Q008:鵪鶉高膽固醇模型飼料,3%膽固醇

TP 3Q010:鵪鶉高膽固醇模型飼料,4%膽固醇

TP 3Q012:鵪鶉高膽固醇模型飼料,5%膽固醇

如果以上模型飼料不能滿足你的要求,請提出!

純化型

以下模型飼料是純化日糧,價格相對較高。

產品代碼    模型飼料名稱               說明

TP 3Q104:鵪鶉高膽固醇模型飼料,0.5%膽固醇

TP 3Q104:鵪鶉高膽固醇模型飼料,1%膽固醇

TP 3Q106:鵪鶉高膽固醇模型飼料,2%膽固醇

如果以上模型飼料不能滿足你的要求,請提出!

2.鵪鶉動脈粥樣硬化用高脂高膽固醇模型飼料

給鵪鶉高脂高膽固醇模型飼料,血漿膽固醇濃度比高膽固醇飼料喂養的鵪鶉要大幅度提高。因此,應當優先考慮選用高脂高膽固醇模型飼料。

下表列出的是南通特洛菲飼料科技有限公司生產的鵪鶉動脈粥樣硬化用高脂高膽固醇模型飼料。

特洛菲飼料科技有限公司
鵪鶉高脂高膽固醇模型飼料

日糧型

以下模型飼料是在本公司鵪鶉標準飼料(低脂)生產過程中添加脂肪和膽固醇,其正常對照飼料應當選用相應的標準飼料。

產品代碼     模型飼料名稱              說明

TP 3Q204:鵪鶉高脂高膽固醇飼料,5%脂肪,0.5%膽固醇

TP 3Q206:鵪鶉高脂高膽固醇飼料,5%脂肪,2%膽固醇

TP 3Q209:鵪鶉高脂高膽固醇飼料,12%脂肪,0.5%膽固醇

TP 3Q212:鵪鶉高脂高膽固醇飼料,15%脂肪,0.5%膽固醇

TP 3Q214:鵪鶉高脂高膽固醇飼料,15%脂肪,2%膽固醇

如果以上模型飼料不能滿足你的要求,請提出!

純化型

以下模型飼料是純化日糧,價格相對較高。

產品代碼    模型飼料名稱               說明

TP 3Q304:鵪鶉高脂高膽固醇飼料,5%脂肪,0.5%膽固醇

TP 3Q306:鵪鶉高脂高膽固醇飼料,5%脂肪,2%膽固醇

TP 3Q309:鵪鶉高脂高膽固醇飼料,12%脂肪,0.5%膽固醇

TP 3Q312:鵪鶉高脂高膽固醇飼料,15%脂肪,0.5%膽固醇

TP 3Q314:鵪鶉高脂高膽固醇飼料,15%脂肪,2%膽固醇

如果以上模型飼料不能滿足你的要求,請提出!

對于上述描述中有不清楚之處或者其他注意事項,請與南通特洛菲飼料科技有限公司技術部聯系。

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